Phospholamban, also known as PLN or PLB, is a micropeptide protein that in humans is encoded by the PLN gene. [5] Phospholamban is a 52-amino acid integral membrane protein that regulates the calcium (Ca 2+) pump in cardiac muscle cells. [6]

Jul 1, 2003 · In mice, phospholamban seems to encumber an otherwise healthy heart, but humans with a phospholamban-null genotype develop early-onset dilated cardiomyopathy.

Dec 1, 1996 · Phospholamban, through its inhibitory effects on the affinity of the cardiac sarcoplasmic reticulum Ca 2+ pump for Ca 2+, represses both the rates of relaxation and contraction in the mammalian heart.

Phospholamban is a key regulator of cardiac contractility and modulates SR Ca2+ sequestration by inhibiting the SR Ca2+-ATPase (SERCA) in its dephosphorylated state. Upon phosphorylation, which is mediated through beta-adrenergic stimulation, the inhibitory effect of phospholamban on the function of SERCA is relieved.

Phospholamban is a protein consisting of 52 amino acids that forms a homopentamer. It has a hydrophilic region containing phosphorylation sites and a hydrophobic domain that anchors it in the membrane.

Phospholamban is a 52-amino acid protein that can be phosphorylated by PKA and CAMKII and dephosphorylated by protein phosphatase 1. This results in reversible regulation of SERCA2a and cardiac contractility ( Fig. 2 ).

A comprehensive discussion is presented of advances in understanding the structure and function of phospholamban (PLB), the principal regulator of the Ca2+-ATPase of cardiac sarcoplasmic reticulum. Extensive historical studies are reviewed to …

Phospholamban (PLB) is a 52-amino acid integral membrane protein that helps to regulate the flow of Ca2+ ions in cardiac muscle cells. Recent structural studies on the PLB pentamer and the function...

Jun 8, 2012 · This review will focus on the regulation of Ca-cycling and contractility by the sarcoplasmic reticulum (SR) Ca 2+-ATPase/Phospholamban (SERCA/PLN) complex and their interacting partners under physiological and pathophysiological conditions in the heart. The role of each Ca-cycling protein in this multimeric complex, which contributes to the ...

Phospholamban (PLB) is a 52 amino acid sarcoplasmic reticulum (SR) membrane protein that reversibly inhibits the cardiac isoform of the SR Ca 2+ ATPase (SERCA2a) in cardiac myocytes (Bers 2002).