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During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...

Treatment of sensitive bacteria with beta‐lactam antibiotics often leads to two salient population‐level features: a transient increase in total population biomass before a subsequent decline, and a ...

GAF domains are ubiquitous motifs present in cyclic GMP (cGMP)‐regulated cyclic nucleotide phosphodiesterases, certain adenylyl cyclases, the bacterial transcription factor FhlA, and hundreds of other ...

NF2 deficiency eliminates LATS-mediated phosphorylation of YAP, allowing dephosphorylated YAP to enter the nucleus and co-activate CAD and DHODH transcription. Together, these enzymes accelerate de ...

Phosphatidylserine (PS) is a phospholipid mainly enriched in the inner leaflet of the plasma membrane; however, its role in the nucleus remains unclear. This study describes the presence of PS in the ...

Several important questions remain as to how to most effectively advance miR-33 inhibition strategies towards improving patient health in a viable drug-delivery strategy and platform. In addition, ...