Here, we report suvanine, a marine sponge sesterterpene, as an antagonist of the mammalian bile acid sensor farnesoid-X-receptor (FXR). Using suvanine as a template, we shed light on the molecular ...

The main drugs associated with agranulocytosis have been antithyroid drugs, sulfasalazine, sulfamethoxazole-trimethoprim, clomipramine hydrochloride, dipyrone with analgesics, the penicillin group, ...

The inclusion of hydrocortisone, progesterone, and testosterone into the cavity of β-cyclodextrin (β-CD) following two possible orientations was investigated using molecular dynamics simulations and ...

An examination into the drug resistance mechanisms at work in P. falciparum, the malaria parasite species which accounts for 90% of deaths worldwide.

Several nongenetic factors may influence lipoprotein (a) levels, including hormone therapy and kidney disease. 75, 76, 77 Treatment of overt hyperthyroidism with thyroidectomy, antithyroid drugs, or ...

The occurrence, type and severity of thyroid dysfunction in offspring is dependent on maternal thyroid status and use of antithyroid drugs, and the presence of antibodies, such as those against ...

The protective effect of antithyroid drug is lost after delivery, however, and the neonate develops clinical hyperthyroidism a few days after birth.

Key Mechanism of Cancer Drug Side-Effect Uncovered European Society of Cardiology New research has uncovered immune changes in cancer patients that could help identify which patients are most at risk ...

This study aims to determine which anti-glioma medication presents the lowest risk for personalized use in clinical patients by assessing the adverse drug reactions (ADRs) associated with these ...

The potential of repurposing cipargamin for treating Babesia species offers both theoretical advancements and practical applications in combating parasitic infections.

Development of new medications is a lengthy and costly process, and drug repositioning might help to shorten the development cycle. We present a machine learning (ML) workflow to drug discovery or ...