This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

Transcription is the process by which an RNA polymerase synthesizes ribonucleic acid (RNA) using deoxyribonucleic acid (DNA) as a template. This study reveals how stochastic transcription ...

“Instead, we discovered that these phosphorylation sites work together but have distinct and opposing effects on RNA polymerase II ... in reduced “nascent transcription,” meaning fewer ...

The RNA cloud formed around genes regulates their readout into RNA. Triplexes help define where in the genome a cloud forms. Proteins and other flipons modulate the levels of gene expression. The ...

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease.

"In lung cancer cells, BRDT can also release paused RNA polymerase II independently ... Ectopic expression of testis-specific transcription elongation factor in driving cancer, Science Advances ...

Single-Molecule Nanoscopy Elucidates RNA Polymerase II Transcription at Single Genes in Live Cells, Cell (2019). Guanshi Wang, Jesse Hauver, Zachary Thomas, Seth A. Darst, Alexandros Pertsinidis.

Heme oxygenase 1 (HO-1) has an influential yet insufficiently investigated effect on Sirtuin 1 (SIRT1), a histone deacetylase ...

Twist Bioscience Corporation’s TWST share price has dipped by 8.55%, which has investors questioning if this is right time to buy.

Blocking CTR1 phosphorylation caused the RNA-copying machinery to slow down, resulting in reduced "nascent transcription ... tunes elongation rate of RNA polymerase II, Molecular Cell (2025).