This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

Transcription is the process by which an RNA polymerase synthesizes ribonucleic acid (RNA) using deoxyribonucleic acid (DNA) as a template. This study reveals how stochastic transcription ...

Failure of a gene-reading quality-control mechanism called Integrator leaves cells littered with abnormal RNA strands that ...

When RNA molecules are synthesized by cells—a critical process in the creation of proteins and other cellular functions—they ...

RNA (ribonucleic acid) is a nucleic acid polymer where the carbohydrate is ribose. RNA is generally single-stranded, as DNA is transcribed by RNA polymerases into mRNA (messenger RNA), which is ...

Failure of a gene-reading quality-control mechanism called Integrator leaves cells littered with abnormal RNA strands that increase cell stress and may contribute to diseases such as cancer and ...

Novo Nordisk has reached an agreement to buy Germany’s Cardior Pharmaceuticals for €1.025 billion ($1.1 billion), adding expertise in RNA therapeutics and a heart failure therapy in mid-stage ...

Despite the efforts of the scientific community, cancer is still a leading cause of death worldwide. Immunotherapy, a ground-breaking strategy for cancer ...