The Mediator complex is a system that regulates protein-coding gene transcription, where mediator of RNA polymerase II transcription subunit 16 (MED16) is a subunit belonging to this system.

This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease.

"In lung cancer cells, BRDT can also release paused RNA polymerase II independently of its bromodomains, as we previously demonstrated, not to be required for Pol II pause/release function of BRD4." ...

We are also refining and applying ultrahigh-resolution spectroscopy techniques to dissect multistep complex biochemical processes ... Single-Molecule Nanoscopy Elucidates RNA Polymerase II ...

miRNA biogenesis and dysregulation in LC The biogenesis of miRNAs is a complex process ... pathway involves transcription of miRNA genes by RNA polymerase II, followed by processing by enzymes ...

CDK9, a core component of positive transcription elongation factor b (p-TEFb) playing a crucial role in RNA polymerase II transcription (RNAP II) initiation to elongation, is a promising target for ...

miRNAs are encoded in our genome and are generally transcribed by RNA polymerase II. Despite the growing evidence for their importance in normal physiology, little is known about the regulation of ...