EurekAlert!11d
Chinese Medical Journal article reveals the anticancer potential of poly ADP-ribose polymerase inhibitors
Poly adenosine diphosphate-ribose polymerase (PARP) inhibitors, a class of targeted anticancer therapies, prevent genetic ...
Repare Therapeutics Provides Business and Clinical Update and Reports Fourth Quarter and Full Year 2024 Financial Results
Repare Therapeutics Provides Business and Clinical Update and Reports Fourth Quarter and Full Year 2024 Financial Results ...
ascopubs.org21d
Clinical outcomes of lutetium-177-vipivotide tetraxetan in men with metastatic castration-resistant prostate cancer at a single academic center.
Efficacy outcomes 12 months after initiation of darolutamide ... testing and poly (ADP-ribose) polymerase inhibitor (PARPi) treatment of patients with metastatic castration resistant prostate cancer ...
ascopubs.org25d
Circulating tumor DNA (ctDNA) monitoring in the assessment and prediction of the efficacy of PARP inhibitors (PARPi).
OCOG-RATIONAL: A phase II randomized trial of optimal recurrence-directed therapy (RDT) without or with androgen-deprivation therapy (ADT) in radio-recurrent oligo-metastatic castrate sensitive ...
Live Law29d
When There Is Ambiguity In Arbitration Agreement, Business Efficacy Test Can Applied To Discern Intent Of Parties To Arbitrate: Bombay High Court
The Bombay High Court bench of Justice Somasekhar Sundaresan has held that when there is an ambiguity in the agreement with respect to arbitration related provisions, the business efficacy test ...
MedPage Today1mon
Epidural Steroid Shots for Back Pain Have Limited Efficacy, Review Shows
In other situations, benefits were unclear or limited. Epidural steroid injections demonstrated limited efficacy in reducing back pain and disability, according to a systematic review from the ...
Frontiers2y
FBXW7 attenuates tumor drug resistance and enhances the efficacy of immunotherapy
Furthermore, FBXW7 has been demonstrated to enhance the efficacy of immunotherapy by targeting the degradation of specific proteins, as compared to the inactivated form of FBXW7. Additionally, other F ...
Frontiers2y
Anti-cancer immune responses to DNA damage response inhibitors: Molecular mechanisms and progress toward clinical translation
PARPi may increase expression of cell death receptor ligands ... The combination of DDRi with DNA-damaging agents has improved the efficacy of these agents in certain contexts. It is now ...