A new study suggests that the spinal cord can differentiate types of pain before the brain is even aware of the injury.

Endocannabinoids bind to cannabinoid receptors throughout ... that endocannabinoids and opioids may not act together in areas of the brain and spinal cord involved in analgesia," Dr. Rajadhyaksha ...

John Streicher, PhD, studies the signaling links between receptor activation and pain relief. Recent research into heat shock protein 90 found that when Hsp90 was inhibited in the spinal cord ...

Research also finds they also have lower pain thresholds, so less stimulation is needed to activate the receptors in the first ... be ways of increasing the number of opioid-releasing Tregs around the ...

Unlike opioids, which work by binding to receptors in the brain and spinal cord, suzetrigine targets sodium channels in the peripheral nervous system before pain signals even reach the brain.

Specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and play a role in the analgesic effects of this drug.

The mechanism of action of fentanyl is best described by its agonist interaction with the opioid µ-receptor ... nervous system via the brain, spinal cord, and other tissues.

Research also finds they also have lower pain thresholds, so less stimulation is needed to activate the receptors ... the number of opioid-releasing Tregs around the spinal cord, or delivering ...