But buprenorphine’s strength as a treatment is also a weakness. Buprenorphine is an opioid. Like methadone, the tightly ...

I am going to have a major abdominal surgery. My doctor says it is likely that I will be needing strong pain medications after. My question is about opioids: How long can you take them and not get ...

Anyone in South Carolina can walk into a store and buy kratom or 7-OH, a powerful derivative of the drug’s active ingredient. Supporters say that it is safe and can help beat opiaite addictions.

This study presents a valuable finding on the role of cholesterol-binding site on GLP-1 receptors and functionally characterizes the impact of this mutation on receptor behavior in the membrane and ...

The nicotinic acetylcholine receptors (nAChRs ... The acetylcholine (ACh)-binding sites on the nAChR are located in the extracellular domain at subunit boundaries, and their structure and drug ...

Our data indicate that these effects are, at least partially, due to the activation of mu opioid receptors present in peripheral sites. These findings provide insight into peripheral contributions to ...

1Children’s Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas. 10Howard Hughes Medical Institute, UT Southwestern Medical Center, ...

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States ...

According to the World Health Organization, opioids include compounds extracted from poppy plants as well as semisynthetic compounds with similar properties that can interact with opioid receptors in ...

The researchers note that lariocidin meets three key criteria for a next-generation antibiotic: a novel structure, a new binding site, and a distinct mechanism of action. Researchers generated a ...

Since medetomidine is so powerful and does not act on opioid receptors, a person who overdoses on it often does not respond to the opioid-reversal drug naloxone, which goes by the brand name ...