Some of them are approved for the treatment of breast and ovarian cancer, for example, olaparib (trade name Lynparza). The proposed method makes it possible to describe the mechanism of clinical ...

Olaparib is an investigational is a first-in ... monotherapy or combination therapy, a different mechanism of action, and molecular type. Detailed analysis of collaborations (company-company ...

"Our precision medicine approach allows us to target the underlying resistance mechanisms to AR-targeted ... in combination with abiraterone acetate, olaparib or 177Lu-PSMA-617, in adults with ...

In the phase 3 PROpel trial (NCT03732820) patients with metastatic castration-resistant prostate cancer (mCRPC) treated with olaparib plus abiraterone in the first-line setting showed significantly ...

Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window A first-line regimen involving pembrolizumab (Keytruda) and olaparib (Lynparza) significantly reduced the risk of ...

However, prolonged exposure to high-concentration oxygen can cause lung injury. The mechanisms of hyperoxic lung injury (HLI) remain incompletely understood, and current treatment options are limited.

Ancient Greece’s priceless Antikythera Mechanism, the world’s first computer displayed at the National Archaeological Museum. Credit: ZDE/Wikimedia Commons/CC BY-SA 4.0 The Antikythera computer ...

The mainstay of treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) remains a combination of androgen deprivation therapy along with standard-of-care androgen receptors ...

memory update mechanisms are not at work. It is worth noting that correlations between TCAQ scores and fear responses in all three groups were not significant in the late phase of acquisition or the ...

Specific features in ACC and its immune evasion mechanisms do continue to complicate successful immunotherapeutic approaches in this disease. Thus, IL-13Rα2 has become an attractive target. Very ...