De-escalating from aspirin plus ticagrelor to aspirin plus clopidogrel 1 month post-percutaneous coronary intervention (PCI) was associated with favorable outcomes in patients with stabilized ...

One- and three-month dual antiplatelet therapy (DAPT) was found to have similar risk for ischemic events in both women and men at high bleeding risk undergoing PCI, according to a study published ...

Our research projects aim to answer clinically relevant research questions in patients with coronary heart disease as well as to advance the understanding of its risk factors throughout the ...

Our research demonstrates that the restoration of ER-mitochondria contacts through the regulation of Notch signaling is sufficient to partially ... cells treated with gamma-secretase inhibitor DAPT.

The Notch signaling pathway regulates developmental cell-fate decisions and has recently also been linked to inflammatory diseases. Although therapies targeting Notch signaling in inflammation in ...

DAPT abolished the protective effect induced by G1 pre-treatment ... 2017). Here, for the first time, Notch signaling, nitric oxide, and cell survival pathway are linked to preconditioning protection ...

Moreover, the development of specific inhibitors of Notch cleavage may be beneficial for the treatment ... we solve a structure in complex with the non-transition-state analogue inhibitor DAPT, which ...