People genetically susceptible to Huntington's disease often see their movement ... or CAG, on one strand of the DNA and cytosine-thymine-guanine, or CTG, on the complementary strand—begin ...

People genetically susceptible to Huntington's disease often see their movement ... or CAG, on one strand of the DNA and cytosine-thymine-guanine, or CTG, on the complementary strand-begin ...

four (Huntington's disease, various spinocerebellar ataxias, Friedreich's ataxia and myotonic dystrophy types 1 and 2) exhibit an unusual expansion of repeat sequences in DNA, and four (ataxia ...

Researchers found that inhibiting GSK-3 led to less defects in the axonal transport process and less neuronal cell death, while inhibiting ERK1 led to more transport problems and more cell death.

The US Food and Drug Administration (FDA) has awarded breakthrough therapy designation to uniQure's AMT-130 for treating Huntington's disease, a rare neurodegenerative condition. This designation ...

Only those observations that indicate a link with DNA repair defects will be mentioned here. Oxidative stress and DNA damage are also implicated in Parkinson's disease. Increased levels of ...

BUFFALO, N.Y. — A decade ago, University at Buffalo researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated huntingtin protein (HTT) cause Huntington’s disease?

They found that two specific signaling proteins, GSK3ß and ERK1, were expressed more in the neurons of Huntington’s disease patients, so they prevented them from functioning in the neurons of ...