experimental acquisition and data analyses approaches using electron microscopy and electron tomography based methods. This protocol describes the optimization of RNA preparation conditions for ...

The BEMS Core Facility (MCDB Department) is an open access user facility that serves the University of Colorado, other non-profit institutions, as well as industry partners worldwide. We have three ...

or Electron Tomography (ET) Electron tomography is TEM based method best suited for high resolution (~1-4 nm/pixel) imaging of relatively small areas. Typical dimensions of ET dataset is about 5.0 x 5 ...

Cryo-EM has made major strides in recent years, enabling high-resolution imaging of biological structures. Cryo-electron tomography (cryo-ET) builds on the core principles of cryo-EM, combining them ...

Other newer screening tests at various stages of investigation are: electron beam computed tomography (EBCT) (Figure 1) which is based on the non-invasive detection of calcium in the walls of the ...

The University of Colorado Boulder Biochemistry Department's Krios Electron Microscopy facility (BioKEM) offers single particle cryo-EM and cryo tomography of plunge-frozen samples. The BioKEM ...

Biominerals, such as sea urchin spines or mollusc shells, are sources of inspiration and envy to materials researchers. These inorganic–organic hybrids have exceptional mechanical properties ...

Published today in Nature, the study describes how scientists used cryo-electron tomography, guided by fluorescence microscopy, to explore deep inside an Alzheimer's disease donor brain.