Drs Olga Brieieva and Martin Higgs discuss in vitro genomic models for predicting clinical resistance to PARP inhibitors for ...

This novel understanding of BRCA2's role in PARP inhibition could significantly influence the development of more effective anti-cancer drugs. The researchers found that intact BRCA2 protects RAD51, ...

The primary job of BRCA2 is to regulate RAD51, a key player in the accurate recombination of DNA during cell division.

More information: Sudipta Lahiri et al, BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments, Nature (2025). DOI: 10.1038/s41586-025-08749-x ...

New Haven, Conn. — Mutations in BRCA2 — a gene known to repair damaged DNA and suppress tumor formation — can predict an individuals’ predisposition to develop breast cancer, ovarian ...

RAD51 immunofluorescence showed that 21% of evaluable samples had a RAD51-low score, indicating HRR deficiency, and a high sensitivity and specificity for identifying tumors with BRCA1/2 alterations.

Patients who have metastatic castration- resistant prostate cancer (mCRPC) and exhibit the BRCA2 mutation often face a challenging prognosis. However, insights shared by David R. Wise, MD, PhD, at the ...

Cooperation between the DNA recombinase RAD51 and the breast cancer susceptibility protein BRCA2 is crucial for the repair of double-strand DNA breaks. Two papers provide new insight into the ...

Together, BRCA2, BCDX2 and RAD51 are the main players in the process that repairs damaged DNA -- called 'homologous recombination'.

Together, BRCA2, BCDX2, and RAD51 are the main players in the process that repairs damaged DNA—called “homologous recombination.” ...

BRCA2’s primary role is to act as a vehicle for RAD51, which can carry up to six of these proteins. By doing so, BRCA2 can remove a protein known as RPA from its position and deposit RAD51 onto the ...

RAD51 is another essential protein in DNA repair, and in order to function, many individual RAD51 proteins need to bind along a single strand of DNA as a filament. However, the way in which BRCA2 ...