Sign up for our NewslettersOriginal storyThe Greenville County Sheriff's Office is actively searching for a man with medical ...

Authorities say 42-year-old Jonathan Kyle Runnels was traveling west on a Honda Motorcycle when he went off the left side of the road and then hit a tree. He was sent to the hospital, where he died ...

Here is a list of free fireworks shows this week in the Upstate area of South Carolina: Fireworks at 9:30 p.m. (If we missed ...

Upstate festivals this summer have something for everyone, from music to plays to food and more. Here's when, where and how ...

ANDERSON COUNTY, S.C. (FOX Carolina) - An Upstate church celebrated two major birthdays on Friday—America’s and its own—by ...

Heat index values are expected to reach the upper 90s to around 100 degrees, increasing the risk of heat-related illnesses.

Two youth baseball coaches have been fired after they were filmed stripping naked and streaking at an upstate New York ...

Now, an Upstate doula care service is hosting an event to educate and support mothers to help them know their rights, and ...

Two other upstate waterways, one in Western New York and one in the Adirondacks, also made the list of the nation's best ...

Upstate Medical University is holding a groundbreaking ceremony for a new, state-of-the-art laboratory called the Upstate ...