Essentiality studies have traditionally focused on coding regions, often overlooking other small genetic regulatory elements. To address this, we combined transposon libraries containing promoter or ...

imageimageThe tubulin/FtsZ superfamily of cytoskeletal proteins may have originated in Asgard archaea. This study reveals different filament morphologies membrane tethering mechanisms for the dual ...

Symbiotic bacteria in long-term host associations frequently undergo extreme genome reduction. While they retain genes beneficial to the host, their repertoire of transcription factors is severely ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The bacterial cell wall is primarily composed ...

Abstract Essentiality studies have traditionally focused on coding regions, often overlooking other small genetic regulatory elements. To address this, we combined transposon libraries containing ...

Phospholipase C gamma 1 (PLCG1) has been identified as the most frequently mutated gene in adult T-cell leukemia/lymphoma, suggesting a critical function of PLCG1 in driving T cell activation. However ...

imageimageSynovial sarcomas is a rare aggressive cancer characterized by aberrant SS18::SSX translocation and altered chromatin accessibility. This multi-screen study identifies SUMO2 as a critical ...

Dynamic reorganization of synaptic vesicles, synapsins, and actin is tightly associated with synaptic activity, but the molecular details of their interactions are not fully understood. This study ...

STING gain-of-function (GOF) mutations cause STING-Associated Vasculopathy with onset in Infancy (SAVI), a severe autoinflammatory disease. Mice carrying STING GOF V154M mutation develop profound T ...