The specificity of T cell recognition is determined by the variable (V) domain of the T cell receptor (TCR ... our efforts on solving the crystal structure of a mouse TCR in complex with an ...

A recently developed cancer treatment called chimeric antigen receptor T-cell therapy (CAR T-cell therapy, for short) offers hope to people whose diffuse large B-cell lymphoma (DLBCL) has proved ...

This report describes a usually mild syndrome, dubbed LICATS, affecting about three-quarters of CAR T-cell recipients.

If you or a loved one has diffuse large B-cell lymphoma (DLBCL) that is no longer responding to treatment or came back after treatment, chimeric antigen receptor (CAR) T-cell therapy may be an option.

CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant. Nature Cancer , 2025; DOI: 10.1038/s43018-025-00934-1 Cite ...

From a meeting that celebrates basic research and being "first," a look at 3 data sets on therapies that would break new ...

T cell therapy called AIC100, which targets the ICAM-1 protein, demonstrated encouraging responses and an acceptable safety ...

Get Instant Summarized Text (Gist) A novel approach using CAR-M (Chimeric Antigen Receptor Macrophages) has been developed to address the limitations of CAR-T therapy in treating solid tumors. By ...

In recent years, CAR-T cell immunotherapy (using chimeric antigen receptors) has revolutionized the fight against cancer. In combination with other tools (chemotherapy, radiotherapy), this new ...

Targeted Oncology provides news, videos, and reviews on the rapidly evolving world of targeted therapies and immunotherapy ...

Chimeric antigen receptor (CAR) T-cell therapies have drastically changed treatment paradigms in relapsed and refractory (R/R) haematological malignancies since the approval of the first CAR-T ...