Gene expression is linked to RNA transcription, which cannot happen without RNA polymerase. However, this is where the similarities between prokaryote and eukaryote expression end. Central to the ...

Once transcription is initiated, the DNA double helix unwinds and RNA polymerase reads the template strand, adding nucleotides to the 3′ end of the growing chain (Figure 2b). At a temperature of ...

This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a node known as the transcription bubble ...

This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

An enzyme called RNA polymerase deciphers this code and converts it into RNA, a molecule that closely resembles DNA. This transfer of life's code from DNA to RNA is called transcription.

There are a variety of different types of RNA polymerases that can transcribe different types of RNA. RNA polymerase II, shown here, is responsible for creating messenger RNA (mRNA), which is the main ...

RNA synthesis, or transcription, is the process by which RNA is produced using DNA as a template. This process is carried out by the enzyme RNA polymerase, which binds to specific promoter regions on ...

The genetic information stored in DNA is transcribed into RNA through the process of transcription. In this process, the enzyme RNA polymerase uses one strand of the DNA as a template to synthesize a ...

This process of protein synthesis occurs in two stages - transcription and translation ... by an enzyme (helicase enzyme). The enzyme RNA polymerase attaches to the DNA in a non-coding region ...

Ibrahim Cissé spent hours as a child taking apart and trying to rebuild electronics. Other times, he would reenact NASA space shuttle liftoffs, tipping a chair backward onto the floor and then ...

Our mission is to elucidate fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in ...

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease.