A phase 1b/2 trial in triple-negative breast cancer will assess LP-184 alone and with a PARP inhibitor in advanced cases.

Ferroptosis evasion often underlies resistance to PARP inhibitors. Sphingosine kinase 1 (SPHK1) drives NRF2 transcription and suppresses ferroptosis via NF-κB p65 activation, thereby conferring ...

MRN Radio, SiriusXM NASCAR Radio). Forty-one drivers are vying for 38 spots, meaning three cars will fail to qualify for the 113-lap event. The qualifying order below is determined via metric that ...

Is the BMW 1 Series a good car? The BMW 1 Series remains a solid entry in the premium hatchback segment thanks to its dynamic driving experience, well-built cabin and strong efficiency.

Detained activist is the latest casualty of pervasive War on Terror pursued by rightwing administration America's discredited, illegal and immoral "War On Terror ...

The season’s 10th race will be broadcast on FOX and MRN at 3 pm ET ... The 188-lap race is divided into three stages. Stage 1 ends on lap 60, Stage 2 consists of 60 laps, and the final Stage ...

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a group of drugs used to treat type 2 diabetes and sometimes obesity. GLP-1 RAs are very effective at lowering blood sugar levels.

Latent autoimmune diabetes in adults (LADA) is an autoimmune condition also known as type 1.5 diabetes. People with LADA follow similar T1D practices with insulin, eating, exercise, and blood ...

Nguyen, Sridevi Challa. Metabolic regulation of PARP inhibitor response in ovarian cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 ...

Carneiro. PARP inhibitor-induced senescent fibroblasts enhance prostate cancer cell proliferation and suppress NK cell-mediated cytotoxicity [abstract]. In: Proceedings of the American Association for ...

See where your favorite NASCAR Xfinity Series driver will pit for the North Carolina Education Lottery 250 presented by Black’s Tire at Rockingham Speedway on Saturday (4 p.m. ET, The CW ...