Modulating nerve fibers can release inhibitory substances at the dorsal horn, such as endogenous opioids (e.g., endorphins, enkephalins), and norepinephrine, which bind to receptors on primary ...

The dorsal horn of the spinal cord represents the first site in the ... primarily mediated by AMPA and NMDA receptors. The firing pattern of APs in DH neurons depends on several factors, including the ...