Inflammatory arthritis as a result of immune checkpoint cancer therapy remains a pressing challenge for patients and ...

Patients older than 65 years had similar clinical outcomes in response to immune checkpoint inhibitors as younger patients with cancer.

IO Biotech's first-in-class vaccine performs double duty, killing cancer cells and enhancing the tumor microenvironment. A ...

Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited tumor-infiltrating lymphocytes (TILs) may be ...

The new study, published April 21 in Nature Communications, bolsters evidence that lifesaving immune checkpoint inhibitors are effective across age groups despite age-related changes in the immune ...

It's well-known that a person's immune system wears down over time, becoming less effective as folks progress through middle age and become seniors. But that doesn't appear to hinder the ...

either as a monotherapy or in combination with immune checkpoint inhibitors such as PD-1 or PD-L1 inhibitors. Other than oncology, the unique MOA as a metabolic regulator also shows the potential ...

These data support the immune-mediated anti-cancer activity of the proposed dual MOA of amezalpat,” said Sam Whiting, M.D., Ph.D., chief medical officer and head of R&D at Tempest ...

known as immune checkpoints. In this article, explore how the research into blocking these checkpoints has led to immune checkpoint inhibitors (ICIs), a promising but still evolving class of ...

A recent case report explains how epitope spread may cause immune checkpoint inhibitor (ICI)–associated bullous pemphigoid (BP). A separate research letter spotlights cases of partial ...

Many modern cancer treatments, such as immune checkpoint inhibitors and cytokine therapies, help the immune system fight cancer. However, these treatments can sometimes harm healthy tissues and ...