Drs Olga Brieieva and Martin Higgs discuss in vitro genomic models for predicting clinical resistance to PARP inhibitors for ...

Women with breast cancer who were also carriers of the BRCA1 or BRCA2 mutation and received textured breast implants as part of their reconstructive surgery after mastectomy were 16 times more ...

RAD51 recombinase nucleates onto ssDNA at the DSB sites and promotes HR. BRCA1 and BRCA2 proteins promote RAD51 filament formation, facilitating HR (Venkitaraman, 2009; Zhao et al, 2019). Mammalian ...

More information: Chiara Merigliano et al, Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51, Molecular Cell (2025). DOI: 10.1016/j.molcel.2025.05.012 ...