Three studies examine how resistance to chemotherapy develops in cancers deficient in BRCA1 and BRCA2. The mechanism involves restoration of BRCA1 and BRCA2 activity. Shah examines the ...

The sequence homology we have previously noted between the activation domain of BRCA2 and the JNK-binding site in c-Jun prompted us to examine whether JNK is binding to BRCA2. Given that JNK can ...

Women with breast cancer who were also carriers of the BRCA1 or BRCA2 mutation and received textured breast implants as part of their reconstructive surgery after mastectomy were 16 times more ...

More information: Chiara Merigliano et al, Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51, Molecular Cell (2025). DOI: 10.1016/j.molcel.2025.05.012 ...

Drs Olga Brieieva and Martin Higgs discuss in vitro genomic models for predicting clinical resistance to PARP inhibitors for ...