Sitagliptin can be combined with metformin and, depending on the therapeutic indication, with further drugs, particularly insulin and sulfonylureas. The G-BA therefore distinguished five research ...

SITAGLIPTIN/METFORMIN MYLAN 50 mg/1000 mg – Oval-shaped, brown colour biconvex, film coated tablets debossed with "S477" on one side and plain on other side (AUST R 386882) ...

Results of the study demonstrated that therapy with ONGLYZA 5 mg was non-inferior to JANUVIA 100 mg when added to metformin (difference in adjusted mean change from baseline vs. JANUVIA plus ...

The base study looked at 412 patients over a year and then included them in an all-patients-treated analysis of efficacy over the next year. Januvia combined with metformin were found to control ...

Sitagliptin (Januvia, Merck) and metformin were begun in combination by 13.2% of the study population, and 15% of these participants eventually started on insulin; 19.1% of those who started on ...

Meeting Coverage > EASD Januvia/Metformin Combo Gets Boost from Novel SGLT2 — T2D patients uncontrolled on duo do better when adding ertugliflozin by Crystal Phend, Senior Associate Editor ...

Previously on sitagliptin alone: initially 50 mg/500 mg twice daily; may increase to 50 mg/1000 mg twice daily. Previously on sitagliptin and metformin: switch on a mg/mg basis.

Metformin and sitagliptin are known to be substantially excreted by the kidney. The risk of metformin accumulation and lactic acidosis increases with the degree of impairment of renal function.

In a 24-week placebo-controlled study of sitagliptin 100 mg as add-on therapy in patients with type 2 diabetes inadequately controlled on metformin and glimepiride (sitagliptin, N=116; placebo, N ...

With the two active components, sitagliptin and metformin, Janumet has a comprehensive mechanism of action that targets all three key defects of T2DM for improved glycemic control: diminished ...