There are several compounds available for investigating the action of S1P receptor signaling in cancer, including the potent S1P 4 antagonist CYM 50358, the highly selective and potent S1P 2 ...

A bitter taste receptor, TAS2R14, has been shown to respond to both extracellular and intracellular signals. Indeed, it can respond to both signals simultaneously.

The LAT Signalosome The models summarized in the Antigen Discrimination and Intracellular Receptor Phopshorylation sections describe T-cell activation up to the point of ZAP-70 binding to the ...

Targeting intracellular checkpoints could be combined with other strategies, such as tumor sensors, immune checkpoint blockade, and synthetic gene circuits, to enhance NK cell immunotherapy.

A new study shows how the single-molecule organization of receptors in a cellular context determines the function of ...

G protein-coupled receptors are the key target of a large number of drugs. Würzburg scientists have now been able to show more precisely how these receptors act in the cell interior.

Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor. The Journal of Cell Biology, 2018; jcb.201711047 DOI: 10.1083/jcb.201711047 ...

DOI: 10.1038/s41589-025-01982-5 Receptors like the one the researchers investigated (known as free fatty acid receptor 4 or FFA4), are part of the large family of G protein-coupled receptors (GPCRs).

However, the researchers found that FFA4 receptors are mainly located inside fat cells, on internal membranes near lipid droplets. When fat is broken down, the released fatty acids immediately ...