In the type 2 diabetes group, the incretin effect amounted to 36 ± 6%, significantly (P < 0.05) lower than in chronic pancreatitis patients with NGT and in healthy subjects, respectively.

This incretin effect is inhibited in those with type-2 diabetes, leading to hampered insulin production. This is why these hormones are currently therapeutic targets for treating insulin levels in ...

There are two types of incretin-based drugs: one serves to block the DPP-4 enzyme and is taken orally; the other is an analogue to the GLP-1 peptide and is an injectable. Neither was found to be ...

The incretin effect—defined as augmentation of the insulin response by gastrointestinal hormones after oral glucose intake compared with administration of glucose intravenously—is impaired in ...

To examine the role of plasma glycemia on the incretin effect, Marzieh Salehi, MD, from the University of Cincinnati, and colleagues gave 13 healthy subjects without diabetes 50g of an oral ...

Distinguishing among incretin-based therapies. Glucose-lowering effects of incretin-based therapies. J Fam Pract. 2010;59 (9 suppl 1):S10-S19. 28. Campbell RK, Cobble ME, Reid TS, Shomali ME.

The incretin effect refers to the observation that, when challenged by glucose delivered via an oral route (as would occur with ingestion of a meal), the resulting increase in insulin levels is ...

This incretin effect is inhibited in those with type-2 diabetes, leading to hampered insulin production. This is why these hormones are currently therapeutic targets for treating insulin levels in ...

Incretin, which plays a key role in maintaining glucose homeostasis, has diminished effects for people with type 2 diabetes. Incretin-based therapies are able to target defects that are not ...

Discussion With the current study, we confirm the observation made by Nauck et al. [3] in 1986 that the incretin effect is reduced in patients with type 2 diabetes, and we conclude that this ...

"The absolute incretin effect is reduced in T2DM; its relative importance, however, appears to be increased, highlighting its role as an important amplifier of first-phase insulin secretion in T2DM." ...