Computational models of the glucoregulatory system constitute a powerful tool for preclinical evaluation and mechanistic insight into therapeutics. However, in the case of diabetes, there is a dearth ...

Overall, the study found that the impaired secretion of glucagon in type 1 diabetes is due to the excessive secretion of somatostatin due to disrupted regulation of δ-cells by the β-cells.

In the study, we investigated how p38 MAPK family members regulate glucagon action. We also looked at the function of the FOXO1 protein.

Rhonda D. Wideman, Irene L. Y. Yu, Travis D. Webber, C. Bruce Verchere, James D. Johnson, Anthony T. Cheung, Timothy J. Kieffer, Improving Function and Survival of Pancreatic Islets by Endogenous ...

They found significant improvements in heart function, including reduced heart stiffness, improved blood-filling capacity and overall better heart performance. The study’s first author, Chen Gao, ...

To re-evaluate glucagon responsiveness, 15 mg. of the same zinc glucagon preparation that the patient had been using was given with prednisone and breakfast. Subsequent blood sugars are shown in ...

Glucagon-like peptide 1 (GLP-1) is a promising candidate for the treatment of type II diabetes. However, the short in vivo half-life of GLP-1 has made peptide-based treatments challenging. Gene ...

A research group led by Profs. WU Beili and ZHAO Qiang at the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences determined the cryo-electron microscopy (cryo-EM) structures ...