Type 2 diabetes (T2D) has become one of the leading chronic diseases worldwide in terms of both incidence and mortality.

Can fish oil really help prevent diabetes? Learn how omega-3s like DHA and EPA may lower blood sugar and reduce T2D risk in ...

GLUT4, the "insulin-responsive" glucose transporter, is sequestered intracellularly, redistributing to the cell surface only in the presence of hormone. To test the hypothesis that the biosynthesis of ...

The process of GLUT4 trafficking is central to the metabolic regulation of blood glucose levels. In both muscle and adipose cells, the insulin hormone triggers the mobilisation of intracellular ...

Inside the cell, GLUT4 was contained in balloon-like structures known as vesicles. The vesicles transported GLUT4 to the cell membrane and merged with the membrane, a process known as fusion.

Muscle GLUT4 content at baseline was similar between the groups. In the placebo group, 2 weeks of immobilization decreased GLUT4 content on an average of 22% (range -10 to -35%, P < 0.05).

Insulin stimulates glucose transport by promoting translocation of the insulin-sensitive glucose transporter isoform 4 (GLUT4) from an intracellular compartment to the cell surface. This movement is ...

GLUT4 messenger RNA and protein are reduced in adipocytes in many insulin-resistant states, 6 often long before type 2 diabetes develops. 20 We previously reported that genetic knockout of GLUT4 ...

They show here that GLUT4 is inserted into the myotube plasma membrane at regions of membrane ruffling, where cytoskeletal remodeling takes place. Perturbing the cytoskeleton with specific drugs ...

In conclusion, the current findings provide strong evidence to suggest that 1) oral creatine supplementation can offset the decline of muscle GLUT4 protein content in skeletal musculature during ...