Mechanism of Action Glucocorticoid receptors are found intracellularly in almost all tissues. Glucocorticoids enter cells through passive diffusion and form a complex with a receptor protein. This ...

Glucocorticoids are fundamental drugs used in the treatment of lymphoid malignancies with apoptotic cell death as the hitherto proposed mechanism of action. Recent studies, however, showed that an ...

All the patients received induction therapy with three 21-day cycles of RVD, which consisted of lenalidomide (25 mg, administered orally on days 1 through 14), bortezomib (1.3 mg per square meter ...

At the interim analysis of the randomized phase III trial ASPIRE (CArfilzomib, Lenalidomide, and DexamethSone versus Lenalidomide and Dexamethasone for the treatment of PatIents with Relapsed Multiple ...

Background: Bortezomib (btz) combined with lenalidomide (len) and dexamethasone (dex) (VRd) is a standard initial therapy for NDMM. Carfilzomib (cfz), a next-generation proteasome inhibitor, in ...

Grade 3 or 4 myelosuppression was more common in patients who received lenalidomide plus dexamethasone in our study than in patients with relapsed or refractory multiple myeloma who received ...

Joffre B. Baker, Gregory S. Barsh, Darrell H. Carney, Dennis D. Cunningham, Dexamethasone Modulates Binding and Action of Epidermal Growth Factor in Serum-Free Cell Culture, Proceedings of the ...

Researchers in England say they have the first evidence that a drug can improve COVID-19 survival: A cheap, widely available steroid called dexamethasone reduced deaths by up to one third in ...

“It would likely be harmful to take dexamethasone as an outpatient treatment for Covid-19,” said Dr. Brown. Patients with mild infections “should not be trying to get people to prescribe ...