“I have had so many different breakthroughs,” Vannessa Cross says in PEOPLE’s exclusive look at Wednesday’s episode of 1000-Lb. Best Friends Vannessa Cross has "changed her life" after ...

During a therapy session shown on Monday's episode of 1000-Lb. Best Friends, Cross, 44, and her best friend Meghan Crumpler meet with their bariatric psychologist, Dr. Connie Stapleton.