Because RNA pol II transcribes ... the purposes of polymerase studies - although recreational mushroom hunters should beware! Thus, while eukaryotic transcription is far more complex than ...

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

"When SPT5 is lost, this ARMC5 mechanism will recognize RNA polymerase II and then eliminate this defective transcription complex." The findings may also inform the understanding of the ...

Three different types of RNA polymerase exist in eukaryotic ... Termination of pol II transcripts, however, is more complex. Transcription of pol II genes can continue for hundreds or even ...

J Biol Chem 2022, 102433. Richter, WF; Nayak, S; Iwasa, J; Taatjes, DJ. The Mediator complex as a master regulator of transcription by RNA polymerase II. Nat Rev Mol Cell Biol 2022, 23: 732 - 749.

This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

The Mediator complex is a system that regulates protein-coding gene transcription, where mediator of RNA polymerase II transcription subunit 16 (MED16) is a subunit belonging to this system.

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease.

miRNA biogenesis and dysregulation in LC The biogenesis of miRNAs is a complex process ... pathway involves transcription of miRNA genes by RNA polymerase II, followed by processing by enzymes ...