This serves two main functions. First, it allows PARP proteins to maintain functionality by returning them to their inactive forms. PARG inhibition results in increases in sensitivity to DNA damage ...

Mutations in BRCA2—a gene known to repair damaged DNA and suppress tumor formation—can predict an individual's predisposition ...

Mutations in BRCA2 — a gene known to repair damaged DNA and suppress tumor formation — can predict an individuals' predisposition to develop breast cancer, ovarian, prostate, pancreatic, and other ...

The PARP & DDR Inhibitors Summit will equip you ... community to optimize & expand current DDR inhibitors including ATR, DNA-PK, PolQ & Rad51 target novel synthetic lethal pairs & develop safe ...

When successful, these cancer treatments cause enough DNA damage to trigger cancer cell death ... unnecessary DNA end cuts become resistant to chemotherapy drugs such as PARP inhibitors. However, ...

Two months after the last chemotherapy, Bianca Balti resumes her battle against cancer. Fresh from participating in the Milan ...

Prostate cancer is the most common cancer in men, and genetic variants in DNA damage repair and response ... with a view to starting them on PARP inhibitor treatment. In 340 cases, the men ...

DelveInsight’s, “Colorectal Cancer Pipeline Insight 2025” report provides comprehensive insights about 195+ companies and ...