Opioids mimic the body's natural pain relievers, binding to receptor proteins in the brain and sometimes inducing euphoria. National Corporate funding for NOVA is provided by Carlisle Companies.

Non-opioid therapeutics for chronic pain are urgently ... pocket that transiently opened beneath the conventional ligand-binding site. Opening of this pocket was facilitated by separation of ...

2006;40(11):2178-2186. The mechanism of action of fentanyl is best described by its agonist interaction with the opioid µ-receptor. These sites of interaction are primarily distributed throughout ...

Despite widespread public health warnings and media attention focused on the dangers of opioid addiction ... on the CB1 receptor that could serve as an additional binding site.