Opioids mimic the body's natural pain relievers, binding to receptor proteins in the brain and sometimes inducing euphoria. National Corporate funding for NOVA is provided by Carlisle Companies.

Non-opioid therapeutics for chronic pain are urgently ... pocket that transiently opened beneath the conventional ligand-binding site. Opening of this pocket was facilitated by separation of ...

2006;40(11):2178-2186. The mechanism of action of fentanyl is best described by its agonist interaction with the opioid µ-receptor. These sites of interaction are primarily distributed throughout ...