This article focuses on one of those potential combination therapies: oncolytic viruses (OVs). In the tug-of-war between fire (immune stimulation) and ice (immune suppression), ice usually wins ...

VP-315 is described as a potential first-in-class oncolytic chemotherapeutic peptide immunotherapy that could induce ...

Key advancements in Verrica’s pipeline include positive data from a Phase 2 study of VP-315, an oncolytic peptide candidate targeting basal cell carcinoma. Additionally, the company plans to ...

Bacillus Calmette-Guérin (BCG) remains the primary treatment for patients with high-risk bladder cancer, but resistance develops in 30% to 40% of cases. The use of oncolytic viruses has emerged as a ...

Other proteins such as H-Ras and Rac1 have been shown to mediate oncolytic specificity in certain systems. The NDV genome allows for stable expression of foreign genes while avoiding the problem ...