DNA ligase I is a 919-amino acid polypeptide, expressed in all tissues, which catalyzes the joining of Okazaki fragments during DNA replication and also plays a role in DNA repair. DNA ligases IIIa ...

One moves continuously to produce the new daughter DNA molecule on the leading strand, whereas the other produces a long series of short Okazaki DNA fragments on the lagging strand. Both ...

The fragments of newly synthesized DNA along the lagging strand are called Okazaki fragments, named in honor of their discoverer, Japanese molecular biologist Reiji Okazaki. Okazaki and his ...