The sequence of these events defines the heterogeneous signs and symptoms of MS with persistent deficits and disability progression. Advances in understanding the underlying pathogenesis paved the ...

A study published in Neurotherapeutics dives into the role of the gut microbiome in the pathogenesis and progression of multiple sclerosis (MS), a chronic | Drug Discovery And Development ...

Targeting TLRs and their signaling cascades can potentially influence MS pathogenesis through effects on neuronal cells, immune cells and MSCs. IFN-γ modulates the immune function and ...

once thought to be spared in MS, has also been shown to be damaged in MS. The damage appears to be due to an inflammatory process in which lymphocytes that can react to CNS tissue become activated ...

Cuprizone is a neurotoxin with copper-chelating ability, and it produces symptoms that are similar to those caused by multiple sclerosis lesions. Multiple sclerosis induced by cuprizone in animal ...

Discover why BTK inhibitors have attracted interest for treating multiple sclerosis, as a few late-stage candidates close in on FDA approval.