Ichthyosis vulgaris is an inherited or acquired skin condition that occurs when the skin doesn’t shed its dead skin cells. This causes dry, dead skin cells to accumulate in patches on the surfac ...

TMB-001 is an investigational topical reformulation of isotretinoin for the treatment of congenital ichthyosis. The phase 3 program evaluating TMB-001 did not meet primary and secondary endpoints.

Figure 1: Clinical appearance of ichthyosis vulgaris. Blood samples were obtained with informed consent from 15 families with ichthyosis vulgaris and from normal ethnically matched controls.