Huntingtin was the first disease ... the G8 DNA probe (Figure 5; Gusella et al., 1983). After determining that the HD gene is located on chromosome 4, the members of the Huntington's Disease ...

Therapeutic development for Huntington’s disease has largely focused on small molecules and antisense oligonucleotides (ASO). The latter are small strands of RNA or DNA that can be designed to ...

four (Huntington's disease, various spinocerebellar ataxias, Friedreich's ataxia and myotonic dystrophy types 1 and 2) exhibit an unusual expansion of repeat sequences in DNA, and four (ataxia ...

People genetically susceptible to Huntington's disease often see their movement ... or CAG, on one strand of the DNA and cytosine-thymine-guanine, or CTG, on the complementary strand—begin ...

The number of people who have the gene that causes Huntington's disease in Northern Scotland has been accurately counted for the first time in 35 years in new research from the University of ...

People genetically susceptible to Huntington's disease often see their movement ... or CAG, on one strand of the DNA and cytosine-thymine-guanine, or CTG, on the complementary strand-begin ...

High dose and low dose AMT-130 demonstrated an 80% and 30% slowing of disease progression vs external control, respectively. The Food and Drug Administration has granted Breakthrough Therapy ...