Computational models of the glucoregulatory system constitute a powerful tool for preclinical evaluation and mechanistic insight into therapeutics. However, in the case of diabetes, there is a dearth ...

In the study, we investigated how p38 MAPK family members regulate glucagon action. We also looked at the function of the FOXO1 protein.

Overall, the study found that the impaired secretion of glucagon in type 1 diabetes is due to the excessive secretion of somatostatin due to disrupted regulation of δ-cells by the β-cells.

When novel formulations of glucagon emerged onto the market by 2019, including intranasal and premixed liquids, their wholesale acquisition costs per kit started just below the cost of unmixed ...

A research group led by Profs. WU Beili and ZHAO Qiang at the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences determined the cryo-electron microscopy (cryo-EM) structures ...

Diabetes is a disease affecting two hormones, insulin and glucagon. In healthy individuals, insulin helps cells take up glucose from the blood when glucose levels are high, and glucagon helps the ...