One way to envision the replication fork ... important site when the cell is replicating DNA. That is the DNA replication fork, which contains the replication machinery performing DNA synthesis.

propels itself rapidly along one of the template DNA strands (here the lagging strand), forcing open the DNA helix ahead of the replication fork. The helicase exposes the bases of the DNA helix ...

However, processes such as the establishment of replication forks and translocation along DNA remain unclear ... Moreover, ATP binding and hydrolysis at one interface were observed to induce ...

In eukaryotes, DNA replication initiates at many replication origins that are distributed along the length of each chromosome arm. At each origin, two replication forks are established that travel in ...

Chromosome Dynamics: Although genetic information is encoded in a one-dimensional array of DNA bases ... in which replicated DNA is linked together as it exits the replication fork, remaining stably ...

RAD52 is one of those proteins ... previously discovered that RAD52 is important in protecting stalled DNA replication forks. Their work suggested that this new function of RAD52 facilitates ...