One way to envision the replication fork ... important site when the cell is replicating DNA. That is the DNA replication fork, which contains the replication machinery performing DNA synthesis.

propels itself rapidly along one of the template DNA strands (here the lagging strand), forcing open the DNA helix ahead of the replication fork. The helicase exposes the bases of the DNA helix ...

However, processes such as the establishment of replication forks and translocation along DNA remain unclear ... Moreover, ATP binding and hydrolysis at one interface were observed to induce ...