BRCA2 and RAD51 associate with telomeres during S phase. RAD51 associates with telomeres during the late S and G2 phases of the cell cycle 9, when telomere capping structures are restored after ...

Cooperation between the DNA recombinase RAD51 and the breast cancer susceptibility protein BRCA2 is crucial for the repair of double-strand DNA breaks. Two papers provide new insight into the ...

Bell manipulated pieces of DNA with a single-stranded gap and exposed them to RAD51 with and without BRCA2 under different conditions. The resulting movies show how BRCA2 chaperones RAD51 onto ...

BRCA2, p53 gene and RAD51. Studies in vivo have shown that the BRCA2 protein forms complexes with the DNA repair protein RAD51 and with the tumor suppressor protein p53.

By visualizing BRCA2 function at a single molecule level, Kowalczykowski’s team discovered that it acts as a molecular chaperone, delivering another protein, RAD51, to single-stranded DNA.

If the BRCA2/RAD51 DNA repair system is not working, the cell resorts to other, more error-prone methods. "It's at the apex of the regulatory scheme of DNA repair," Kowalczykowski said.

BRCA2 helps RAD51 molecules to assemble on strands of broken DNA and form filaments. The RAD51 filaments then search for matching strands of DNA in order to repair the break.

More information: Sudipta Lahiri et al, BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments, Nature (2025). DOI: 10.1038/s41586-025-08749-x Provided by Yale University ...

image: BRCA2 (red) helps RAD51 (yellow) form short filaments on strands of broken DNA (blue), enabling it to look for matching strands of DNA and repair the break. view more .

Genomic analysis revealed that the most frequently altered genes included TP53, PTEN, AR, MYC, BRCA2, ... RAD51 ...

This novel understanding of BRCA2's role in PARP inhibition could significantly influence the development of more effective anti-cancer drugs. The researchers found that intact BRCA2 protects RAD51, ...

BRCA2 modulates distinct states of RAD51 filaments. Credit: Nature (2025). DOI: 10.1038/s41586-025-08749-x Mutations in BRCA2—a gene known to repair damaged DNA and suppress tumor formation ...