These revealed 27 germline BRCA2 variants (6%), but only two germline BRCA1 variants (0.5%), and one of these probably wasn't the driver as an ATM mutation was also present, note the researchers.

Clarke, PhD, professor at The Hormel Institute, University of Minnesota, is the author of a paper appearing in the scientific ...

Genetic and genomic testing guide breast cancer risk assessment and treatment, as discussed by Dr. Mark Robson at the Miami ...

BRCA1/2 mutation carriers exhibited a more pronounced pathologic complete response rate, especially with carboplatin. The study predates the immunotherapy era, necessitating contextual interpretation ...

This shocking news started her down a path she never imagined, including two more significant medical developments: the discovery she had the BRCA gene mutation, and a skin cancer diagnosis.

The presence of biomarkers, even in small amounts, can shape the course of treatment for a patient, says Andy Guinigundo, MSN, RN, CNP, ANP-BC.

Instead, each individual cancer draws on a collection of acquired mutations that endow ... had variants in BRCA1 and BRCA2 genes. Patients with this cancer type had an earlier cancer onset if they ...

[38,39] Risk-reducing strategies have been shown to have associations with a gain in life expectancy in BRCA1/2 carriers. Moreover, extended life expectancy can range from between a few months to ...

It is indicated for use in patients with cancers with a specific germline BRCA mutation, and have responded to the most recent course of platinum-based chemotherapy in adults. The drug is also ...