Those killed in Iran include the military's top echelon and nuclear scientists. Israel said it also killed a second commander of the Guards' overseas arm, whom it identified as Benham Shariyari, during an overnight strike. Nour News on Saturday named 15 air defense officers and soldiers it said had been killed in the conflict with Israel.

Israel has targeted Iran's largest nuclear facility in an airstrike on Saturday, according to an official in the Islamic republic. Israeli sources reported the destruction of Isfahan nuclear research complex although Iranian state media said there was no leakage of hazardous materials from the strike.

By Alexander Cornwell and James Oliphant JERUSALEM/WASHINGTON (Reuters) -Iran and Israel exchanged fresh attacks early on Saturday, a day after Tehran said it would not negotiate over its nuclear programme while under threat and Europe tried to keep peace talks alive.