Running backs have traditionally been the choice if you've owned the No. 1 overall pick in your Fantasy football drafts. However, it's an injury-prone position because of all the high-impact contact and occasionally a wide receiver or even a quarterback (depending on your league settings) comes along to insert themselves in the conversation.

Jake Meiners praised his team's performance in the Trojans' 39-12 season-opening win over Lawrenceburg Aug. 22, 2025.

Considering that the average fantasy football league consists of 10-12 teams, one should be able to find solid starting/flex RB options within the top 35 or so. You start running into backup/handcuff territory after that and whether it’s due to an injury or simply outplaying their spot on the depth chart,

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