Skopje is the capital and largest city of North Macedonia. It lies in the northern part of the country, in the Skopje Valley along the Vardar Ri…Skopje is the capital and largest city of North Macedonia. It lies in the northern part of the country, in the Skopje Valley along the Vardar River, and is the political, economic, and cultural center of the country. As of the 2021 census, the city had a population of 526,502. Skopje covers 571.46 km² and includes both urban and rural areas, bordered by several municipalities and close to the borders of Kosovo and Serbia.